Games with Permanent Debuff/Cursed Equipment/Stat or Level Drain type deal

[Hazunya]

Games like Monstergirl Dream, Succubus Tower, Princess Colosseum are pretty fitting for the description.

Wonder if theres anymore game that the Hero/Heroine are weakened over time because of event/losing or choices.

 

[ChupacabraGonzales]

Mission Mermaiden Hasumi and Deep Sea Sisters

 

[someonebored]

Lilith Battle! [RJ139078] has some stats+level drain, too, it's from the same circle that developed Succubus Tower.

 

[pleaserefrainfromjudging]

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Valkyrie Destruction, by Poison kind of has it. The MC is an evil bandit who level drains a holy valkyrie and then travels with her. He can sleep with her to give her one of his levels, but if she gains more levels than him she'll beat him up and leave.