Re: [粗製]ボクの奴隷娼館
Slaves lose sanity anywhere, maybe even cells and showers over time. It's just much slower in chair/bed/couch room than in glory hole. You can get through the entire game only exchanging the fancier room girls about 2-3 times (Though they will be making crap profits if you stretch them that far).
It's actually best to exchange slaves when they're low yellow or red sanity. If you check their income, it lowers dramatically to the point where buying another cheap AH slave with max sanity would make up for the cost fairly quickly. Low sanity/cleanliness really hurts profits. Of course once you have like 16+ slaves it's nice to have things as automated as possible, I ended up with 4 bathhouses surrounding them all after day 31 or 32 when the major taxes end. Made things so nice.
Early game I used the 2nd auction house girls in all the fancy rooms and used the 1st auction house girls for glory holes. Eventually when I got the 3rd AH, I used those girls in the fancy rooms and used the 2nd AH girls for glory holes. The 2nd AH girls only cost like 450-700 and will pay themselves off fairly quickly in the glory hole if you exchange them at low yellow/red sanity at that point.
Luckily I just made it to the "happy gas" upgrade before my 70+ beauty girls from the 3rd AH became mind broken in the fancier rooms, I really didn't want to have to exchange them. At that point I just put 70+ beauty girls everywhere, including Glory Holes. With the 2nd gas upgrade and 2 rooms of it, you can even keep Glory Hole girls healthy.
I also finally managed to get an std at about day 55, the doctor fixes it without any noticeable penalty. Got one the next day too, both from Glory Hole. Not sure if later days or using the Glory Hole increases the chance of it happening or what.