I've done it consistently with Dorothy + Nudity.
Seriously, the fact that Nudity increases Dorothy's damage is silly. Bloodthorns basically either kills everything, or brings them so low that only a few hits from allies will deal with them.
You will need to hope for some good holy water drops though, as your arousal will be constantly increasing and you can start racking impurity fairly early.
The added benefit though is that you don't have to worry about the stones, as you can't recover your clothes anyways.
TBH though, while it's fun to play, I wish the dungeons were a bit longer and the impurity increase less. The sensitivity increases almost never matter because by the time they get to stage 1 you're basically completely corrupted.
I was messing with cheat engine, but the fact that it rotates EVERY room makes it incredibly frustrating. I wanted to mess with the game more but I'm not sure i'm super interested in grinding out more points. :/
Yeah, I can feel that. Though, as long as you don't mind it being a completely unhealable stat, there is at least one Boon I know of that seemingly reduces the build up of Impurity by a good chunk, at the cost of never being able to heal it again. Got it once while in a dungeon at an altar, and that plus the virgin buff kept me from ever going very high, even once the virgin buff had been lost on a couple characters. Nellie got her mind rocked by Arum, and still managed to only be at round half or so from memory, could be a bit fuzzy on whether it was a bit above half though. WAs enough to surprise me either way.
Only thing I really wish for at this point, and its mostly me being a glutton for RNG/punishment, is some of the rooms had more randomness to them towards the end of areas. The catacombs in particular is one that, the final room where you have two teleporters, one to a group of enemies, the other to a chest, the left one is ALWAYS a chest, and the right ALWAYS the enemies. Does at least feel like it rewards you for remembering what is what though, which is good in itself, but I'm always a sucker for those odds of being utterly screwed given the nature of the game.
But yeah, haven't bothered with cheat engine yet, and the nudity buff/debuff, plus the one that decreases durability for clothes not only feels like an amazing way to make dorothy a one tap champ, but also to really scale up the amount of rewards you can earn. The "things explode sometimes" one is also a really easy way to get some tiny bit of extra points, cause as far as I've seen, it just makes some barrels explosive during the ruins section, not sure if it does much else. Might make weapons explode on breaking at times? But haven't really noticed it yet. The repair between rooms boon however, is easily the easy mode of the game, allowing you to stock up on all the best weapons, which by the end game means 2-3 bloodthorn spells fully charged for dorothy, plus still decent weapons for sera and nellie. Gives me enough to reliably blast through the Arachne now even without the nudity having been tried yet. All in all, theres a lot of tools there to make the melee characters even more valuable and useful if you are dedicated to them, and Seras charge being a reliable "get off me/my friends" move is pretty handy. Gonna eventually try an unarmed run with her specifically just to see howit goes, though, it'll probably end at the Arachne queen if the unarmed damage increase boon isn't too significant in the end. Fun fact about the repair boon too, it repairs power cells between rooms, which last me until about the succubus fight generally and really do add that extra bit of Oomf to everything everyone does, most notably of course Dorothy, the absolute legend.
That said, I still find myself generally using Nellie up until the final stages of the game, and leaving the ai to cast stone/lightning just so I have the speed of the melee characters to run through much of the game, while dealing pretty solid damage with the fire explosion AoE, even if its still significantly under what a buffed up dorothy, or even base dorothy can do.