I hope we can get different endings with each character. I quite like the twins and Nono.
None of the girls beside Alice or Amy feel like canon that's for sure.
In the game
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one of the heroines is Charlotte. In fact, she's the tutorial fight in that game. Same voice actor and everything. The fact that she's fuckable in this game as well means she's getting around. I doubt she'll ever be considered "main" heroine material. Honestly, first heroine I've seen that actually moves from game to game like this.
Alice is the only one that mentions she wants to stay in a sexual relationship with you even after you wake up, and gets jealous over you at times. Amy's the main focus of the story narratively. Not only does she like Riddle sexually, but it's shown she likes him in that way as well through all of the main events she's a part of.
None of the other characters are really heroine material imho. The succubi are well succubi. They don't have just a little bit of sexual experience before meeting you but A LOT. They all see you as another delicious meal. No emotional attachment. The twins are mostly goofballs. Sheep, and Rose are just after their next meal, and Succubus is a succubus. Literally seen having sex with another guy before her level down event. Nono's the only small exception and maybe Lilith.
The way they wrote Lilith and Nono though, I really don't see it. They kinda meet you and randomly become obsessed with you? It's so weird.
I feel like I might've said this before but while this game is hot, and well produced, it's got extremely weak emotional ties for the heroines. Well the game's not perfect. It's hard to have fantastic heroines like MGQ or Sequel Blight, where there's a strong emotional bond that makes sense along with sexual desire as well. That kind of perfect eroge hasn't been made yet XD
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Hmmm... Now that I think about it. P.D Creation's The World a Robot Girl Dreams of did come close. The enemies in that game aren't really treated like heroines so the actual heroines are really fleshed out, and there's a pretty good emotional bond there. That game has a host of other small problems, but thinking back, it's definitely slightly superior to Lilith In Nightmare.