By itself, not really, actually. The parts where Nona being a futa actually does really matter is few. There's the futa village, of course, the onahole pillar where you insert the dick inside the wriggling hole, and the harpy boss fight where the chicks will all try to make Nona impregnate them, so that they can then later insert their fertilized egg into Nona's womb.
In all other instances since the futa village, like for example the worms, the flesh tree, fly swarm and the fly queen, the tit-enlarging plant and guardian scorpion, the the anal fly and spider, the cliff goblins, the entire swamp and so on, it wouldn't actually matter if Nona were standard or futa. He just draws her with an erect penis from arousal in the game over scenes, because it makes sense that this organ would be worked upon as well when she's defeated anyway. But that shouldn't really count as futa content by itself.
The problem is simply the very slow work progress. And said slow work progress can ultimately only be solved if somebody were to throw ludicrous amounts of money to eluku's banking account so that he wouldn't need to work otherwise for a living.