Tried doing it on the hardest difficulty a while back before I had my time taken up with translation stuff. Depends on how you play it. If you go in with a full or mostly full Compendium it shouldn't be that hard. When I was doing it on a fresh file, it was going pretty smoothly up until Iron Maiden 2. I think that would be a main pain point (I remember her going easier on you if you have max corruption now with a patch), but after that it should be pretty doable up until Daji as long as you allocated your stats right.