Let's talk about what we know about Setaria, these games are in the same world and we see that Setaria started thanks to a statue:
"once upon a time there was a girl who came across a curious statue and made a wish "I wish that we can all live being loved without having to go hungry or have war""
Why did a girl make a wish on the statue? easy this girl is a Dwarf and it is known that the dwarfs used the statues for decoration and perhaps praise.
thanks to that desire we know that,
1.- the statue was corrupted by the influence of the black moon
2.- The statue and the girl's pure desire served as a catalyst for dimensions to open up and give way to Corruption, at least in Setalia.
about anika
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We see that there is a stained glass window in the church that resembles our protagonist from setalia
is anika a dwarf?
I don't know but from its appearance it may be a yes.
I'm not clear about the chronology of events, perhaps setalia is a sequel to lutellaria, what is the basis for saying that?
the fairy of the end,
It gives us a clue that the fairies started coming out after the corruption ended but then the corruption came back thanks to the girl's wish making the fairies lustful and following us in Setalia.
then we can say,
first there were the events of lutellaria, but there were still effects of the black moon and it made the corruption return.
we know thanks to the end of setaria that the corruption continued despite having defeated the girl fused by the statue
thus leaving two dimensions open.
1.in the mansion where the giant is
and
2 the "meat expand"
so maybe if there is a setalia sequel maybe we will see 1 ruby and anika working together to seal the spreading evil.