I made the suggestion that the second ability lets you choose which Disaster card you get back, not one randomly, and the Big Boobs ability either makes every Curse card this turn (even those you draw later that turn) 2 mana cheaper, or the next Curse card you play is 4 mana cheaper / costs 0 mana.
I feel right now the biggest issue is the legendary squeezer:
CT009=3,GD004=3,GD009=3,GD010=3,GD016=3,MC001=3,MC004=3,MC006=3,MC016=3,SC001=3,SC002=3,SC004=3,SC007=3,SC999=1,p=SC999,n=Marianera Last Longer
From round 3 onward the opponent has to sacrifice a permanent card each turn. This alone fucks up any deck that relies on a few but powerful cards. You yourself have a ton of cheap cards to flood the board with more guardians the opponent can handle; with the addition of the Cheerleader squeezer you can even buff all your guardians to kill off the opponent's guardians.
Most decks will properly need Extreme Heat (2 damage to all guardians) or Big Earthquake (3 damage to all guardians) to beat this deck.
Having 3 Harapeko so you can create mana crystals with Big Boobs so you have something to sacrifice also has become more important.
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Also, this is the deck I was talking about regarding the Immoral Sister:
CS005=3,CT006=3,MC001=3,MC004=3,MC005=3,MC006=3,MC007=3,MC008=3,SC001=3,SC003=1,SC004=3,SC005=3,SC006=3,SC007=3,p=SC003,n=Infinite Energy Curse
However, as it does not deploy many guardians it is very vulnerable to Trafficker and Marianera.
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edit:
Another deck that is hard to counter:
CT006=3,MC001=3,MC004=3,MC005=3,MC006=3,MC007=3,MC008=3,MC013=3,SC001=3,SC003=1,SC004=3,SC005=3,SC007=3,TC022=3,p=SC004,n=Infinite Energy Harapeko
The goal is quite simple: Survive long enough until you have Infinite Energy up, then quickly draw your deck thanks to An Accelerating Civilization. Keep one Breastfeeding on your hand, and once you have at most 3 cards left in your deck get 7+ energy to play Wisdom unsealed, buff her with Breastfeeding (and draw 1 card), and as she has now 2 Breastmilk you can immediately use her second ability, drawing your last 2 cards and win instantly as she is now unsealed and you have no more cards in your deck.
Use Big Boobs on your Harapeko to create mana crystals to counter Marianera.
As an alternative win condition I have Boobs Save The World; with 3 Bunny Girls, 3 Cheerleaders and 1 Big Boobs Harapeko you only need to buff one other squeezer with Big Boobs to be able to win that way. Not sure if I wanna keep it though, maybe I switch Boobs Save The World with Curse Return to protect The Secret Of Imagination and Infinite Energy.
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edit2:
I'm really looking at the card Epidemic right now. That card seems really good actually...
I find it very weak as it requires that one 1Life guardian survives.
You cannot simply cast a very powerful guardian and have it take 1 damage each turn.